Polio's Cancer Fun

Polio's Cancer Fun is a hack of Super Mario Bros by Sex Pistols members Johnny Rotten and Sid Vicious. The intention for the game was to turn "a massive smash hit into nothing but cancer".

Mario is replaced by Polio, a character infected with Polio and testicular cancer, who must save Princess Smallpox, his girlfriend who was diagnosed with AIDS and smallpox, from the Grim Reaper, who himself is infected with every type of cancer known.

His brother is Lupus, a gay Mexican male prostitute with lupus, HIV, heroin addiction, and severe terminal brain cancer. The mushrooms are replaced with cancer cells.

Development
In 1998, the Sex Pistols reunited, 20 years after disbanding. During this reunion, former bassist Sid Vicious, who died of a heroin overdose in February 1979, miraculously showed up.

Happy to see him again, lead singer Johnny Rotten decided to hang out with Vicious for a bit.

During this time, they brainstormed a video game that would change the face of gaming forever.

So, they decided to hack Super Mario Bros, a smash hit 1985 game by Nintendo, and turn it into the most shocking video game to ever be made.

They called Nintendo to see if they could modify the game and release it as their own, but they declined.