Osmosis Jones 2: Body Works

Osmosis Jones 2 is a 2028 American live-action/animated comedy-adventure film produced by Warner Bros. Animation and Conundrum Entertainment. Directed by the Farrelly brothers, it is a sequel to 2001's Osmosis Jones and stars the voices of Chris Rock, David Hyde Pierce, Brandy Norwood, Ron Howard, William Shatner, and Anthony Mackie with the live-action talents of Madisyn Shipman, Molly Shannon, and Bill Murray. In the film, Ozzy and Drix are back in action when a new and even more deadly virus enters the body of Frank Detorre. It was released on July 21, 2028, by Warner Bros. Pictures. The film received mixed reviews from critics and grossed $314 million worldwide.

Synopsis
When a new virus enters Frank Detorre's body, it is up to Osmosis "Ozzy" Jones and Drixenol "Drix" Koldreliff to put an end to his reign of disease.

Cast
Voice cast Live-action cast
 * Chris Rock as Osmosis "Ozzy" Jones, a police officer from the City of Frank Police Department (CFPD), Drix's partner and best friend, Leah's boyfriend, and the main protagonist of the film.
 * David Hyde Pierce as Drixenol "Drix" Koldreliff, Ozzy's partner and best friend.
 * Brandy Norwood as Leah Estrogen, Phlegmming's former secretary and Ozzy's girlfriend.
 * Ron Howard as Tom Colonic, the new mayor of the City of Frank.
 * William Shatner as Phlegmming, the former mayor of the City of Frank who now works as a janitor and is secretly a CFPD undercover agent.
 * Ryan Gosling as a new and deadly virus who's name is unknown that enters the City of Frank.
 * Anthony Mackie as Wilson Jones, Ozzy's father.
 * Joel Silver as the police chief, Ozzy and Drix's boss.
 * Carlos Alazraqui as a lung.
 * Rodger Bumpass as an animated version of himself.
 * Laurence Fishburne as Thrax who makes a flashback cameo from the first film.
 * Bill Murray as Frank Detorre, a zookeeper and health expert who is attacked by an unknown virus.
 * Madisyn Shipman as Shane Detorre, Frank's daughter. She was previously portrayed by Elena Franklin in the first film.
 * Molly Shannon as Mrs. Boyd, Shane's science and P.E. teacher who formerly had a restraining order on her father.
 * Chris Elliot as Bob Detorre, Shane's uncle and Frank's brother and boss.